|
|
|
|
|
Click Here to return To Results
|
|
|
|
We treated 75 patients with drug-resistant complex partial seizures and secondarily generalized seizures with vigabatrin as additional therapy for 6 months.Twenty-one patients either showed no benefit from vigabatrin treatment or had side effects.The remaining 54 patients entered into the long-term study.The median monthly seizure frequency decreased from 12.5 at baseline to 3.3 at the 3-month visit,and was 3.9 after 5 years of therapy in 28 patients who continued using the drug after the 5-year period.During 5 years of therapy with vigabatrin,26 patients have withdrawn from the study because of various reasons:loss of efficacy(14), suspected side effects(5),noncompliance(3),administrative reasons(2), pregnancy(1),and epilepsy surgery(1).In all,19 patients had a greater than 50%seizure frequency reduction at 5 years,representing 35%of the 54 patients who entered the long-term study,or 25%of the 75 patients who were initially recruited into the efficacy study. |
|
(click to filter results - removes previous filter)
seizure
seizure,focal
seizure,intractable
seizure,intractable,treatment of
seizure,psychomotor-temporal lobe
seizure,treatment of
vigabatrin
|
Click Here to return To Results
|
|